Vitamin D Binding Protein (VDBP) significantly increases during pregnancy. This increase leads to a decrease in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D during pregnancy.
- JONES K.S. (2016)
Vitamin D expenditure is not altered in pregnancy and lactation despite changes in vitamin D metabolite concentrations.
Scientific Reports 6, Article number: 26795.
https://www.ncbi.nlm.nih.gov/pubmed/27222109
- SCHWARTZ J.B. (2014)
A comparison of direct and calculated free 25(OH) Vitamin D levels in clinical populations.
J.Clin. Endocrinol. Metab., 99(5):1631-7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010704/
- BIKLE D. (2013)
Variability in free 25(OH) vitamin D levels in clinical populations.
- Steroid Biochem. Mol. Biol., S0960-0760.
https://www.ncbi.nlm.nih.gov/pubmed/24240067
- THADHANI R. (2010)
First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia.
Hypertension, 56(4):758-63.