Obesity

Vitamin D Binding Protein (VDBP) concentrations are significantly higher in obese persons. This increase leads to a decrease in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D in obese populations.

  • BIKLE D. (2013)

Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.

J.Clin. Endocrinol. Metab., 98(11):4400-9.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816263/

  • KARLSSON T. (2014)

Increased vitamin D-binding protein and decreased free 25(OH)D in obese women of reproductive age.

Eur. J. Nutr., 53:259–267.

https://www.ncbi.nlm.nih.gov/pubmed/23604494

  • MIRAGLIA DEL GIUDICE E. (2015)

Bioavailable Vitamin D in Obese Children: The Role of Insulin Resistance.

J Clin Endocrinol Metab. 2015 Oct;100(10):3949-55.

https://www.ncbi.nlm.nih.gov/pubmed/26317560

  • WALSH J.S. (2016)

Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health.

  1. Engl. J. Med. 374(17): 1695-1696.

https://www.ncbi.nlm.nih.gov/pubmed/27169839