Vitamin D Binding Protein (VDBP) significantly decreases in case of kidney disease. This decrease leads to an increase in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D during kidney disease.
- COYNE D.W. (2012)
Bioavailable vitamin D in chronic kidney disease.
Kidney Int., 82:5–7.
- THADHANI R.I. (2012)
Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients.
Kidney Int., 82:84–89.
- DENBURG M.R. (2013)
Vitamin D bioavailability and catabolism in pediatric chronic kidney disease.
Pediatr. Nephrol., 28:1843–1853.
- REBHOLZ C. (2015)
Biomarkers of Vitamin D Status and Risk of ESRD.
Am J Kidney Dis. 2015 Oct 13. pii: S0272-6386(15)01161-0.
- VIVEKANAND J. (2015)
Bioavailable vitamin D levels are reduced and correlate with bone mineral density and markers of mineral metabolism in adults with nephrotic syndrome.
Nephrology (Carlton) Oct 1.