Vitamin D Binding Protein (VDBP) significantly decreases in case of liver failure. This decrease leads to an increase in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D during liver failure.
- BIKLE D.D. (1986)
Free 25-Hydroxyvitamin D Levels Are Normal in Subjects with Liver Disease and Reduced Total 25-Hydroxyvitamin D Levels.
- Clin. Invest., 78:748-752.
- REESE P.P. (2012)
Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation.
Liver Int., 32(2):287-96.
- BIKLE D. (2013)
Variability in free 25(OH) vitamin D levels in clinical populations.
- Steroid Biochem. Mol. Biol., S0960-0760.
- SCHWARTZ J.B. (2014)
A comparison of direct and calculated free 25(OH) Vitamin D levels in clinical populations.
J.Clin. Endocrinol. Metab., 99(5):1631-7.
- BIKLE D. (2015)
Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.
Liver Int. 2015 Mar 11.