Liver failure

Vitamin D Binding Protein (VDBP) significantly decreases in case of liver failure. This decrease leads to an increase in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D during liver failure.

  • BIKLE D.D. (1986)

Free 25-Hydroxyvitamin D Levels Are Normal in Subjects with Liver Disease and Reduced Total 25-Hydroxyvitamin D Levels.

  1. Clin. Invest., 78:748-752.

https://www.ncbi.nlm.nih.gov/pubmed/3745436

  • REESE P.P. (2012)

Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation.

Liver Int., 32(2):287-96.

https://www.ncbi.nlm.nih.gov/pubmed/22098635

  • BIKLE D. (2013)

Variability in free 25(OH) vitamin D levels in clinical populations.

  1. Steroid Biochem. Mol. Biol., S0960-0760.

https://www.ncbi.nlm.nih.gov/pubmed/24240067

  • SCHWARTZ J.B. (2014)

A comparison of direct and calculated free 25(OH) Vitamin D levels in clinical populations.

J.Clin. Endocrinol. Metab., 99(5):1631-7.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010704/

  • BIKLE D. (2015)

Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.

Liver Int. 2015 Mar 11.

https://www.ncbi.nlm.nih.gov/pubmed/25757956