Vitamin D Binding Protein (VDBP) significantly varies in acute stress due to rapid fluid shifts. This variation leads to a significant change in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D during acute stress.
- MADDEN K. (2015)
Critically Ill Children Have Low Vitamin D–Binding Protein, Influencing Bioavailability of Vitamin D.
Annals of the American Thoracic Society, Vol. 12, No. 11 (2015), pp. 1654-1661.
https://www.ncbi.nlm.nih.gov/pubmed/26356094
- DE PASCALE G. (2014)
Vitamin D status in critically ill patients: the evidence is now bioavailable!
Critical Care, 18:449.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095727/
- QURAISHI S.A. (2012)
Vitamin D in acute stress and critical illness.
Curr. Opin. Clin. Nutr. Metab. Care, 15(6):625-34.