Vitamin D Binding Protein (VDBP) concentrations are significantly higher in obese persons. This increase leads to a decrease in the free 25OH Vitamin D concentration, at constant total 25OH Vitamin D levels. Therefore several research groups have studied the importance of free 25OH Vitamin D in obese populations.
- WALSH J.S. (2016)
Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health.
- Engl. J. Med. 374(17): 1695-1696.
https://www.ncbi.nlm.nih.gov/pubmed/27169839
- MIRAGLIA DEL GIUDICE E. (2015)
Bioavailable Vitamin D in Obese Children: The Role of Insulin Resistance.
J Clin Endocrinol Metab. 2015 Oct;100(10):3949-55.
https://www.ncbi.nlm.nih.gov/pubmed/26317560
- KARLSSON T. (2014)
Increased vitamin D-binding protein and decreased free 25(OH)D in obese women of reproductive age.
Eur. J. Nutr., 53:259–267.
https://www.ncbi.nlm.nih.gov/pubmed/23604494
- BIKLE D. (2013)
Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.
J.Clin. Endocrinol. Metab., 98(11):4400-9.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816263/